The Small Molecule Analysis Laboratory (SMAL) at CDT-CARD is a state-of-the-art analytical facility specializing in the study and characterization of small molecules across various scientific and industrial applications. Equipped with advanced instrumentation, SMAL offers comprehensive capabilities for qualitative and quantitative analysis, ensuring precise and reliable data generation tailored to complex research challenges.

Key areas of expertise include high-performance liquid chromatography coupled with mass spectrometry (UHPLC/MS and UHPLC/HRMS), gas chromatography with mass spectrometry (GC-MS) or flame ionization detection (GC-FID), and capillary electrophoresis coupled with mass spectrometry (CE/MS). These methods support the analysis of a wide range of compounds, from volatile organic compounds to biologically active molecules, metabolites, and ionic species.

The laboratory specializes in advanced techniques such as thermodynamic and kinetic solubility assessments, chemical stability testing, and quantitative analysis of ionizable compounds. It also offers imaging capabilities through Desorption Electrospray Ionization (DESI), enabling spatial distribution analysis of molecules within biological tissues. Additionally, the lab provides validated methods for solvent residue analysis and the study of volatile compounds in complex matrices.

The SMAL is equipped with cutting-edge instruments, including Waters Xevo TQ-S Cronos, Waters Synapt XS, Thermo Fisher Trace 1610 with ISQ 7610, and Agilent 7100 CE/MS systems. These tools enable a broad analytical range, from targeted and untargeted mass spectrometric workflows to routine chromatographic analyses.

With a dedicated team of experienced scientists, the SML is committed to providing tailored solutions for standard and custom analyses, fostering innovation in fields such as medicinal chemistry, environmental science, and biotechnology.

The laboratory’s combination of high-end technology and scientific expertise ensures its position as a trusted partner in small molecule research and analysis.